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CATHELICIDIN - Dissertations.se

1. Sam : 17 4. Sir : 46 : 5. Schibbol.c . 1. 00:37 • April 13th, 2021.

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Yang et al (2000) LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J.Exp.Med. 192 1069 PMID: 11015447. 2020-08-04 · The human antibacterial and immunomodulatory peptide LL-37 is a hCAP-18 protein cleavage product that self-assembles. Here, the authors present the human and gorilla LL-37 (17–29) crystal LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human could help protect the cornea from infection and modulates wound healing. LL-37 – Cationic host defence peptides such as LL-37 are key components of innate defenses against infection, with both microbicidal and host defense modulatory functions.

I-M. Frick, P. kesson, M. Rasmussen, A. Schmidtchen, L. Bj rck.

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LL-37 is an antimicrobial peptide which belongs to the cathelicidin family. It serves as an important role in the first line of defense against infection and systemic invasion of pathogens at sites of inflammation and wounds. LL-37 has been successful in promoting would healing but it may play a negative role in atopic dematitis and psoriasis. LL-37 Activates cGAS-STING, TLR, PAMP, DAMP immune system detection pathways, and interferon immune response.

It has been shown to have antimicrobial activity against multiple Gram-positive and Gram-negative human pathogens.
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I-M. Frick, P. kesson, M. Rasmussen, A. Schmidtchen, L. Bj rck. 2003.
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II . 35 . ll . 35 . II . 36 Il 36 . II .